AcceGen

Tumor cell lines (or cancer cell lines) are derived from the cancerous growths on an organ in a human or animal subject. These cell lines have undergone laboratory modifications that render them immortalized—they are capable of proliferating indefinitely in an  in vitro  environment. For that reason, tumor cell lines have become invaluable tools in the field of cancer research.   History of Human Cancer Cell Lines In the first half of the 20th century, various experiments demonstrated that animal cell lines could be maintained in an  in vitro  environment. The first human cell line was established in 1951, from cervical carcinoma cells taken from 30-year-old Henrietta Lacks. The  HeLa cell line , as it’s called, is regarded as a major milestone in medical history, being not only the first immortalized cell line but also an important aid in the development of the polio vaccine.     In 1990, the  U.S. National Cancer Institute  officially launched the NCI-60 project, which consists of si

Cell therapy  has been identified as an effective method to regenerate damaged tissue. Bone marrow-derived mononuclear cells (BM-MNCs) were first reported on a therapeutic angiogenesis for treatment of the ischemic heart in 2000. And the abundant reserve of BM-MNCs in the bone marrow (BM) can avoid the problem of  in vitro  cell expansion. Therefore, in the past decades bone marrow MNCs transplantation has been applied clinically for various ischemic diseases such as acute myocardial infarction, chronic ischemic cardiomyopathy and so on [1].   What is  BM-MNCs ? Bone marrow is a very heterogeneous compartment with multiple cell populations. The term BM-MNC is simply used to collectively denominate all cells present in BM whose nuclei are uninoculated or rounded and lack granules in the cytoplasm. These characteristics give the BM-MNCs a similar density and size, which is different from that of myeloid cells and red-cell progenitors, making them easy to separate by physical means. Among