AcceGen

  Bioluminescence  is a powerful imaging modality for monitoring molecular and cellular features in real time [1].   Luciferases , known as bioluminescent enzymes, can catalyze the oxidation of small molecule substrates, such as luciferins, to release visible light. Currently, the luciferase reporter gene is a highly versatile tool for   in vitro  and   in vivo  assays and the corresponding reporter assay is extremely sensitive, reproducible. Therefore, luciferases have been employed as efficient reporters in a wide range of applications, including gene regulation and signaling, protein-protein interactions, drug screening, molecular imaging, cell-based assays, and noninvasive   in vivo  imaging [2-3].   Luciferases Luciferases originates from luminescent organisms, such as terrestrial and marine organisms. And here luciferases are mainly classified into two categories: D-luciferin-dependent luciferases and coelenterazine-depen...

Immunotherapy  is believed to be one of the most promising areas of cancer research and treatment in the 21 st  century. As it is known that the immune system defends the body against infections. Immunotherapy can boost or change how the immune system works so it can find and attack cancer cells.   Immunomodulatory  regimens have been proven to produce fewer side effects than medication. For example, it is less likely to create resistance when treating microbial disease. Therefore, immunotherapy has attracted great interest from researchers, clinicians, and pharmaceutical companies, especially in terms of its promise to treat various cancers. There are many types of immunotherapy, including monoclonal antibodies and tumor-agnostic treatments, oncolytic virus therapy, T-cell therapy, Cancer vaccines, etc.   T cells, or T lymphocytes , play a key role in cell-mediated immunity. T cells can recognize, track, and fight against foreign particles in the body. CAR-T Ce...